This Journal of Enterprise Information Management Special Issue seeks to understand Agentic Artificial Intelligence and Generative AI (GenAI) in healthcare, and how these technologies impact the governance, strategy, and value creation of healthcare organizations. In technological innovation, digital technologies are reconfiguring value creation processes and prompting organizations to develop new adaptive strategies. In healthcare, this transformation is driving the adoption of innovative solutions to enhance value for stakeholders while supporting more personalised, predictive, and preventive models of care. AI and GenAI are emerging as strategic levers for optimising resource allocation, supporting new care delivery paradigms, and accelerating research and development. The rapid emergence of Agentic AI systems introduces a further step in this transformation, with AI technologies moving from reactive tools towards semi-autonomous systems able to plan, coordinate and monitor actions across complex organizations.
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